Identification of Hypoxia Induced Epigenetic Changes in the Development of Pancreatic Neuroendocrine Tumors Abstract #969

Introduction: In VHL syndrome, pancreatic NETs develop through bi-allelic inactivation of VHL with subsequent HIF pathway activation. This also occurs in sporadic pancreatic NETs.
Aim(s): We sought to determine the epigenetic modifications occurring in VHL-related tumorigenesis in PNETs.
Materials and methods: VHL knockdown in the human pancreatic NET cell line BON1 was carried out by lentiviral transduction. Cells were cultured in normoxic and hypoxic [1% O2] conditions for 1, 4, 8, 16, 48, 72 and 168 hrs. Genome-wide methylation analysis was performed using Infinium HumanMethylation450 Arrays and gene expression analysis was performed using Illumina HT12 arrays.
Conference: 11th Annual ENETS Conference (2014)
Category: Basic Science - Genetics, epigenetics, miRNAs
Presenting Author: Dr Harpreet K Dibra

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