Ileal Neuroendocrine Well-Differentiated Tumors: Prognostic factors with Focus on Loss of Succinate Dehydrogenase (SDHB) Expression Abstract #942

Introduction: Ileal Neuroendocrine Well-Differentiated Tumors (INWDT) are the most common neuroendocrine neoplasms in the gastrointestinal tract. Gene mutations of SDH complex drive pathogenesis of cancer cells through their role in angiogenesis and cell proliferation.
Aim(s): To investigate the expression of SDHB levels in INWDT as a prognostic marker.
Materials and methods: One hundred patients with G1-G2 stage IV INWDT were selected. 76/100 patients had surgery on the primary tumor (T). We studied those patients through 138 samples. Mitotic index (MI), immunohistochemistry for SDHB and Ki-67 were carried out in 76 T and 62 liver metastases (M). SDHB was assessed according to the staining intensity, scored 1 (low) or 2 (high) on the basis of the internal control represented by normal cell
Conference: 11th Annual ENETS Conference 2014 (2014)
Category: Pathology, grading, staging
Presenting Author: MD, PhD Massimo Milione

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