Immunhistochemical Expression of Somatostatin Receptors in Gastroenteropancreatic Neuroendocrine Tumors Using IRS- and Her2-scoring Scheme

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Introduction: Gastroenteropancreatic neuroendocrine tumors (GEP-NET) are known for an overexpression of somatostatin receptors (SSTR). This finding has already gained importance in diagnostics and therapy of NET.

Aim(s): To achieve an immunhistochemical quantification of all 5 SSTR-subtypes and an evaluation of an implementable scoring system (Her2/IRS).

Materials and methods: In 34 patients with GEP-NET, 44 different tumour tissues were immunhistochemically analysed using polyclonal antibodies for SSTR1 and 3-5 and the monoclonal antibody UMB-1 for SSTR2A. SSTR expression was quantitatively evaluated according to HER2-score and IRS, correlated among each other and individually with clinical/ histopathological parameters.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Peter L, Kaemmerer D, Lupp A, Saenger J, Schulz S,

Keywords: gastroenteropancreatic neuroendocrine tumor, somatostatin receptor, UMB-1, immunhistochemistry, IRS,