Immunhistochemical Expression of Somatostatin Receptors in Gastroenteropancreatic Neuroendocrine Tumors Using IRS- and Her2-scoring Scheme Abstract #183

Introduction: Gastroenteropancreatic neuroendocrine tumors (GEP-NET) are known for an overexpression of somatostatin receptors (SSTR). This finding has already gained importance in diagnostics and therapy of NET.
Aim(s): To achieve an immunhistochemical quantification of all 5 SSTR-subtypes and an evaluation of an implementable scoring system (Her2/IRS).
Materials and methods: In 34 patients with GEP-NET, 44 different tumour tissues were immunhistochemically analysed using polyclonal antibodies for SSTR1 and 3-5 and the monoclonal antibody UMB-1 for SSTR2A. SSTR expression was quantitatively evaluated according to HER2-score and IRS, correlated among each other and individually with clinical/ histopathological parameters.
Conference: 8th Annual ENETS Conference (2011)
Category: Clinical
Presenting Author: Luisa Peter

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