Immunohistochemical and Genomic Evidence for the Expression of Somatostatin Receptors 1-5 and Dopamine Receptor 2 in Lung Carcinoids

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Introduction: Expression of somatostatin receptors (SSTRs) and dopamine receptor 2 (DR2) in neuroendocrine tumors is of clinical importance, as they represent potential targets for diagnosis and treatment.

Aim(s): To examine the expression of the five SSTR subtypes and DR2 subtype in lung carcinoids (LCs) by means of immunohistochemistry (IHC) and real time polymerase chain reaction (RT-PCR)

Materials and methods: A retrospective study of 119 LCs from 106 patients [typical carcinoids (TCs) n=100, and atypical carcinoids (ACs) n=19] was conducted. The expression of all five SSTR subtypes and DR2 was evaluated by IHC and correlated to clinocopathological data. In a subgroup of cases, receptor expression was further analyzed using RT-PCR. SSTR expression was also correlated to Octreoscan data.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Kanakis G, Grimelius L, Spathis A, Tringidou R, Rassidakis G,

Keywords: lung, carcinoid, somatostatin ,