Immunohistochemical and qRT-PCR-Based Evaluation of Somatostatin Receptor 1 to 5 Expression in 92 Patients with Bronchopulmonary Neuroendocrine Neoplasms

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Introduction: Little is known about the somatostatin receptor (SSTR) status in bronchopulmonary neuroendocrine neoplasms (BP-NEN), comprising typical carcinoids (TC), atypical carcinoids (AC), small cell lung cancer (SCLC) and large cell neuroendocrine lung carcinomas (LCNEC).

Aim(s): To investigate the SSTR1, 2A, 3, 4 and 5 expression in BP-NEN to provide an additional diagnosis and treatment option.

Materials and methods: A total of 242 formalin-fixed, paraffin-embedded specimens from 26 TC, 30 AC, 35 SCLC and 1 LCNEC were examined by immunohistochemistry (IHC) using specific antibodies and three semiquantitative scores for evaluation. Twenty serial paraffin slides each from the TC, AC and SCLC were randomly selected for qRT-PCR analysis.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Specht E, Kaemmerer D, Wirtz R, Sänger J, Schulz S,

Keywords: somatostatin, bronchopulmonary, NEN, qRT-PCR, immunohistochemistry,