Immunohistochemical Expression of Connective Tissue Growth Factor and Insulin-like Growth Factor-1 in Lung Carcinoids

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Introduction: Several studies have shown altered expression of Insulin-like Growth Factor-1 (IGF-1) and its receptor (IGF-1R) in different types of cancers. Connective Tissue Growth Factor (CTGF) is triggered by Serotonin (5-HT) and Hypoxia Induced Factor 1 (HIF-1) and has been associated with tumor expansion and desmoplastic reaction in carcinoid tumors.

Aim(s): To examine CTGF, HIF-1, 5-HT IGF1- and IGF1R expression in Lung Carcinoids (LC).

Materials and methods: Retrospective immunohistochemical study of 121 LC [103 Typical(TC) and 18 Atypical(AC)] obtained from 104 patients (60 Female) with a mean age of 52 yrs (16-82). Tumors were considered positive if immunoreactivity (IR) appeared in the majority of tumor cells. Urine 5-hydroxyindoleacetic acid (U-5HIAA) was determined in 29 patients.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Kanakis G, Grimelius L, Kaltsas G, Tsolakis A,

Keywords: lung, carcinoid, CTGF, IGF-1,