Immunohistochemical Profiles in 81 Patients with Resected Insulinomas

#2192

Introduction: Ninety percent of insulinomas are benign. However, there are no well-defined immunohistochemical criteria that can distinguish a benign from a malignant insulinoma

Aim(s): We aimed to evaluate the immunohistochemical profiles of benign and malignant insulinomas

Materials and methods: The cohort (n=81, age 52 ± 15 years) was recruited from 1989-2014 from two NET Centers of Excellence. Diagnosis was based on Whipples triad. All patients with a resected insulinoma were included. Immunohistochemistry evaluation was performed by central reading of a NET specialist pathologist (BF). Results were divided in 3 groups: Negative (<5% of cells with positive staining), intermediate (5-50%) and positive (>50%)

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Andreassen M

Authors: Andreassen M, Ilett E, Slater E, Wiese D, Hansen C,

Keywords: insulinoma, malignancy, immunohistochemistry,