Impact of Ki-67 Proliferative Index on Survival in Patients with Typical and Atypical Pulmonary Carcinoids

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Introduction: Currently pulmonary carcinoids are separated into typical and atypical tumors based on mitotic count and presence of necrosis, according to the WHO classification. Whereas for GEP NETs the ENETS Guidelines have been incorporated into the WHO classification and grading is based on mitotic counts and Ki-67 index, the use of the Ki-67 index for grading pulmonary carcinoids is still under debate.

Aim(s): Therefore we evaluated the prognostic impact of Ki-67 assessment in a multicenter cohort and compared different methods (digital assessment or manual counting) of Ki-67 analysis.

Materials and methods: Ki-67 was analyzed in 203 WHO classified carcinoids (149 TCs, 54 ACs), using digital image analysis (in-house Leica Qwin program; ≥4500 cells counted) and manual analysis (500 cells counted). The frequency of Ki-67 positive cell nuclei was correlated with overall survival by univariate analysis and in comparison to clinical data by multivariable analysis.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Rudelius M

Authors: Rudelius M, Swarts D, Cleutjens J, Claessen S, Volante M,

Keywords: pulmonary carcinoids, Ki-67, MIB-1, classification,