Impact of VEGF and VEGFR Polymorphisms on Neuroendocrine Tumors of the Gastro-Entero-Pancreatic System (GEP-NET) Outcome.

#1249

Introduction: Improving our understanding of the molecular biology of GEP-NETs represents a key challenge in the treatment of these rare tumors.

Aim(s): We aimed to analyze genotypes of VEGF-A, VEGFR2 and Flt4 in GEP-NETs and their potential correlation with the risk of these tumors and/or with the outcome.

Materials and methods: The genomic DNA of 28 consecutive patients with GEP-NETs treated at our Institution was extracted from paraffin-embedded tissue. We selected polymorphisms in the following genes: VEGF-A (rs2010963G>C, rs699947A>C), VEGFR-2 (rs2305948C>T, rs1870377T>A) and VEGFR-3 (rs307826T>C, rs307821C>A). Gene polymorphisms were determined by Real-Time PCR using TaqMan assays.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Berardi R

Authors: Berardi R, Pagliaretta S, Rinaldi S, Morgese F, Partelli S,

Keywords: Angiogenesis, Prognosis, Neuroendocrine tumors,