In Vitro Anticancer Effect of Metformin on Neuroendocrine Tumor Cells

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Introduction: Patients with multiple endocrine neoplasia (MEN) type 1 develop pancreatic NETs as well as bronchus carcinoids. No prophylactic drug is available yet. Metformin has been reported to act on the AMPK/mTOR signalling pathway and exhibit antitumoral activity in several cancer cell lines.

Aim(s): To characterize a potential role for metformin as a prophylactic antitumoral drug in MEN-1 patients.

Materials and methods: Human pancreatic neuroendocrine BON1 cells and bronchopulmonary H727 cells were treated with different concentrations of metformin (0.1mM – 10mM) and the effects on cell viability and various signaling pathways (Western Blot) were examined.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Vlotides G, Tanyeri A, Zitzmann K, Spampatti M, Spöttl G,

Keywords: neuroendocrine tumor, MEN-1, metformin,