In Vivo Expression of Survivin and XIAP in Medullary Thyroid Carcimoma

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Introduction: Medullary thyroid carcinoma (MTC) accounts for approximately 5 % of all thyroid malignancies. Although surgery remains the first line therapy with curative intention, for advanced MTC current chemotherapeutic regimes do not provide promising results. Consequently, the identification of biologically relevant biomarkers that are associated with MTC progression may provide novel therapeutic targets.

Aim(s): Aim of this study was to analyze the expression of Inhibitor of apoptosis protein (IAP) family members survivin and XIAP in MTC specimen.

Materials and methods: Tissue microarrays were constructed from MTC tissue specimens of 79 patients who underwent curative surgery for MTC between 1986 and 2003. The percentage of immunohistochemically positive cells and staining intensity of survivin and XIAP was evaluated by using immunoreactivity score (IRS).

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Werner T

Authors: Werner T, Riemer J, Dizdar L, Wolf A, Cupisti K,

Keywords: MTC, IAP, survivin, XIAP,