Incremental Benefit of Preoperative Endoscopic Ultrasound for the Detection of Pancreatic Neuroendocrine Tumors: A Meta-Analysis

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Introduction: Current guidelines recommend computed tomography (CT) scan or magnetic resonance imaging as the initial imaging modalities for the work-up of suspected pancreatic neuroendocrine tumors (PNETs).

Aim(s): To determine the incremental benefit of preoperative endoscopic ultrasound (IBEUS) for the detection of suspected PNETs after other investigative modalities have been attempted.

Materials and methods: This systematic review searched MEDLINE, EMBASE, bibliographies of included articles, and conference proceedings for studies reporting original data regarding the preoperative detection of PNETs. Pooled IBEUS was calculated using random effects models. Heterogeneity was explored using stratified meta-analysis and meta-regression. Evidence of small study effects was assessed using funnel plots and Begg’s test.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Tsolakis A

Authors: Tsolakis A, James P, Zhang M, Belletrutti P, Mohamed R,

Keywords: Pancreatic neuroendocrine tumor, Radiological investigation, Incremental benefit, Endoscopic Ultrasound,