Insulin-like Growth Factor-1 Receptor (IGF-1R) and its Inhibition in Non-functioning Neuroendocrine Tumors

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Introduction: Insulin-like growth factor-1 receptor (IGF-1R) was reported to be expressed in NET (neuroendocrine tumor) cells but its biological roles and activation status in non-functioning NET are unknown.

Aim(s): To study the biological roles of IGF-1R and its inhibition in non-functioning gastrointestinal NET (NFGINET) in 74 patients and two cell lines.

Materials and methods: Immunoreactivity of two forms of phosphorylated IGF-1R (p-IGF-1R:Y1135/Y1136 and Y1161) and its downstream factors in the intracellular signaling pathway (p-mTOR, p-ERK, p-4EBP1 and p-S6) were evaluated. The efficacy of IGF-1R inhibitor II (IGF-1Ri II) on proliferation and downstream factors above was studied in NCIH727 and COLO320 cell lines.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Sasano H, Iida S, Ono K, Nakamura Y, Miki Y,

Keywords: IGF-1R, mTOR, non-functioning neuroendocrine tumor, immunohistochemistry,