Interference of Nutrient/Oxygen Availability with mTOR Activation and Inhibition in Lung Carcinoids: A Tissue and Cellular Study Abstract #945

Introduction: MTOR is capable of coupling cellular nutrient sensing to metabolic homeostasis. However, little is known of the interactions between cancer‐specific metabolic pathways and profiles of responsiveness to mTOR inhibition in neuroendocrine tumors.
Aim(s): To analyze the interference of nutrient availability with mTOR pathway activation and inhibition in lung carcinoids.
Materials and methods: TMA blocks including 75 typical and 19 atypical carcinoids were tested using immunohistochemistry for mTOR pathway molecules (p‐mTOR, p‐S6K, p‐AMPK, p‐RAPTOR, RICTOR) and nutrient transporters (GLUT‐1, SLC6A14, LAT‐1). Rapamycin sensitivity of neuroendocrine tumor cell lines (lung H720, pancreatic BON‐1 and C-cell TT) was tested under glucose deficiency or increased availability and hypoxia.
Conference: 11th Annual ENETS Conference (2014)
Category: Basic Science - mTOR and other pathways, signalling, receptors
Presenting Author: Prof Marco Volante

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