Intraoperative Gamma Probe Detection of Metastatic Medullary Thyroid Carcinoma (MTC) with 111In-Pentetreotide

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Introduction: MTC is a rare thyroid malignancy representing approximately 5-10% of all thyroid tumors. Early diagnosis and radical surgery are essential to reduce the morbidity and mortality associated with MTC. Somatostatin receptors (SSTRs) expression has been described in MTC with a variable pattern, SSTR2 being prevalent. Although somatostatin analogues demonstrated poor efficacy in the control of MTC growth, SSTR expression can be useful in Nuclear Medicine diagnostic procedures. 111In-pentetreotide scintigraphy and 68Ga-somatostatin analogues PET-CT represent valuable techniques in the detection of MTC, although with a lower sensitivity compared to 18F-DOPA PET-CT.

Aim(s):

Materials and methods: We present the case of a 49-year-old male patient affected by MTC with lymph node metastases diagnosed in 1994 when he underwent total thyroidectomy and bilateral laterocervical node dissection, with persistent high calcitonin levels during the follow-up and no detectable residual disease at radiological imaging. In 2011, an ultrasound showed a left latero-cervical lymph node suspicious for localization of disease, confirmed by FNAB. 68Ga-DOTANOC PET-CT showed increased radiopharmaceutical uptake in the same site.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Iacovazzo D, Piacentini S, Lugli F, Fusco A, Perotti G,

Keywords: mtc, srs,