Intrinsic Gene Programs in Metastasis-like Primary Subtype Is Associated with Early Metastatic Evolution in Pancreatic Neuroendocrine Tumours Abstract #2963

Introduction: Three molecular subtypes of pancreatic neuroendocrine tumours (PanNETs) have been described: insulinoma-like, intermediate and metastasis-like primary (MLP). The Latter is a non-functional tumours with highly metastatic potential. A mouse model of PanNET showed that MLP subtype has two different pathways of progression including stem/progenitor and epithelial-to-mesenchymal transition. However, the evolution of metastasis in patients requires further studies.
Aim(s): To determine if MLP subtype-specific early metastasis is due to its intrinsic metastatic/stemness gene programs using in silico statistical modelling of gene expression and patient survival data.
Materials and methods: We analysed the gene expression profiles of 65 (of >200) PanNETs with molecular subtypes and clinical information and outcomes. In silico modelling was performed using a novel cause-effect tool, and univariate and multivariate statistics.
Conference: 17th Annual ENETS Conference 2020 (2020)
Category: Basic Science - Genetics, epigenetics, miRNAs, Omics
Presenting Author: Dr Anguraj Sadanandam

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