Introduction: The main treatment for Pheochromocytoma and Paraganglioma is surgery. However these tumors are highly vascularized, suggesting the possible role for anti-angiogenic agents in the medical therapy. Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor (TKI), mainly described to inhibit VEGFR
Aim(s): To verify the effects of Sunitinib on human Pheochromocytoma and Paraganglioma primary cultures
Materials and methods: 5 primary cultures (4 Pheochromocytoma and 1 Paraganglioma) were obtained from patients, followed in our centre, whose data about age, genetic alteration, histological features, and clinical events had been collected. Cell viability and apoptosis were measured by ATPlite and Caspase 3/7 assay.
Conference: 12th Annual ENETS Conference 2015 (2015)
Category: Basic Science - In vitro models, tumor growth, CTCs
Presenting Author: Dr Teresa Gagliano
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Introduction: P/P are rare tumors sporadically associated with familial disorders. In advanced/unresectable disease, no standard treatment has so far been well established. Recently a mutation of some genes (SDHB, SDHC, SDHD) involved in the pathogenesis of familial P/P was discovered. These mutations are often associated with an over-expression of HIF-1, which plays a central role in angiogenesis and cell proliferation. This pathway is known to be inhibited by some targeted therapies, such as sunitinib or sorafenib.
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Category: Clinical cases/reports
Presenting Author: MD Sara Pusceddu
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