Iodinated Exendin-4 Shows Improved Pharmacokinetic in Rat Insulinoma Model

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Introduction: GLP-1 receptor is an important marker for imaging benign insulinomas.

Aim(s): The limitations of existing PET tracers are high kidney uptake and low specific activity. We attempted to improve these by using radioiodinated (Ex-4).

Materials and methods: Kd and Bmax of [Nle14,125I-Tyr40-NH2]Ex-4 (125I-Ex-4) were determined in in vitro binding assay using Ins-1E rat insulinoma cells. Biodistribution of 125I-Ex-4 was studies in nude mice bearing rat Ins-1E xenografts.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Läppchen T, Tönnesmann R, Meyer P, Maecke H, Rylova S,

Keywords: GLP-1, insulinoma,

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