KI-67 HETEROGENEITY IN GASTRO-ENTERO-PANCREATIC NEUROENDOCRINE TUMORS

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Introduction: The neuroendocrine tumor (NET) proliferation-based grading system (ENETs/WHO) has proved reliable for prognostic stratification, however concerns exist on Ki67 heterogeneity.

Aim(s): Our aim was to evaluate intratumor Ki67 index heterogeneity in primary and metastatic sites.

Materials and methods: A total of 170 GEP-NETs (between 1993-2011) were identified, 50 of them with clinical follow-up (mean follow up was 59 months, range 2-168 months). Twenty-five cases had multiple paraffin blocks on which Ki67 immunohistochemistry was performed.

Conference:

Presenting Author:

Authors: Grillo F, Albertelli M, Calamaro P, Borra T, Bruno S,

Keywords: neuroendocrine tumor, grade, heterogeneity,