Liver Transplantation for Metastatic Neuroendocrine Tumor: A Case Series and Proposed Selection Criteria Abstract #530
Introduction: Liver transplantation (LT) for neuroendocrine tumor (NET) metastases is associated with a high risk of tumor recurrence. Patient selection is the key to future success and its increased utilization.
Aim(s): We report our institutional experience with four cases of LT performed for metastatic NET and propose a set of selection criteria based on the available literature.
Materials and methods: Retrospective review.
Conference: 9th Annual ENETS Conference (2012)
Category: Clinical
Presenting Author: Dr. Douglas Quan
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Keywords:
DNA methylation, CpG dinucleotides, genome-wide, differentially methylated region (DMR)
References:
Duerr EM et al Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis. Endocr Relat Cancer. 2008 Mar;15(1):243-56
Kulke MH et al O6 –methylguanine DNA methyltransferase deficiency and response to temozolomide-based therapy in patients with neuroendocrine tumours. Clin Cancer Res 2009; 15(1): 338-345
Mikkelsen TS et al Dissecting direct reprogramming through integrative genomic analysis. Nature. 2008 454(7200):49-55.
Shen L et al Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18654-9.
