Localisation of Insulinoma and Beta-Cells: Comparison of Glucagon-Like Peptide-1 Receptor (GLP1-R) SPECT/CT, PET/CT and MRI. Preliminary Results of a Prospective Clinical Study. Abstract #1057

Introduction: SPECT/CT imaging with GLP1-R specific radiotracers like 111In-DOTA-exendin-4 have already proved to be a useful tool for the preoperative localisation of insulinomas. PET/CT has several advantages over SPECT/CT: lower radiation exposure, less time consumption and higher spatial resolution.
Aim(s): We aimed at prospectively comparing the detection rate of GLP1-R PET/CT vs GLP1-R SPECT/CT vs standardized contrast enhanced 3T MRI in patients with hyperinsulinemic hypoglycemia.
Materials and methods: Eleven adult Patients with neuroglycopenic symptoms due to endogenous hyperinsulinemic hypoglycemia were enrolled. Contrast media enhanced 3T MRI was performed. SPECT/CT imaging was performed with 111In-DOTA-exendin-4 and PET/CT with 68Ga-DOTA-exendin-4. Gold standard was the histological diagnosis.
Conference: 12th Annual ENETS Conference (2015)
Category: Imaging (radiology, nuclear medicine, endoscopy)
Presenting Author: Dr. Christof Rottenburger

To read results and conclusion, please login ...

Further abstracts you may be interested in

#1802 Sensitivity of Glucagon-Like Peptide-1 Receptor (GLP1-R) SPECT/CT, PET/CT and MRI for the Localization of Benign Insulinomas: Interim Analysis of a Prospective Imaging Efficacy Study
Introduction: 40 patients (pat.) with positive whipple trias were enrolled (ClinicalTrials.gov, NCT02127541).
Conference: 14th Annual ENETS conference (2017)
Category: Imaging (radiology, nuclear medicine, endoscopy)
Presenting Author: Dr. Antwi Antwi
Authors: Antwi A, Fani M, Heye T, Nicolas G, ...
Keywords: insulinoma, GLP-1R
#2003 Comparison of Glucagon-Like-Peptide-1 (GLP-1) Receptor PET/CT, SPECT/CT and 3T MRI for the Localisation of Insulinomas: Evaluation of Accuracy in a Prospective Crossover Imaging Study
Introduction: Benign insulinomas are the most prevalent cause of endogenous hyperinsulinaemic hypoglycaemia (EHH) in adults and due to their small size difficult to localise.
Conference: 15th Annual ENETS conference (2018)
Category: Imaging and Interventions (radiology, endoscopy)
Presenting Author: Dr. Antwi Antwi
Authors: Antwi A, Heye T, Fani M, Nicolas G, ...
#477 Glucagon-Like Peptide 1 Receptor (GLP-1R) Imaging for the Preoperative Localization of Benign Insulinomas in 30 Patients
Introduction: Biochemical diagnosis of endogenous hyperinsulinemic hypoglycemia is straightforward. Surgical removal of an insulinoma is hampered by difficulties to localize it using conventional radiological procedures. In vitro data suggest that human insulinoma cells exhibit a high density of GLP-1R. 111In-exendin-4 is an 111In labeled GLP-1R agonist that binds with high affinity to GLP-1R and may be helpful in localizing insulinomas.
Conference: 9th Annual ENETS Conference (2012)
Category: Clinical
Presenting Author: MD, PhD Emanuel Christ
Authors: Christ E, Forrer F, Wild D, Clerici T, ...
#1230 Ga-68 Somatostatin Receptor PET/CT in the Detection of Insulinoma
Introduction: Presence of somatostatin receptors on beta cells of pancreas is a matter of debate.
Conference: 12th Annual ENETS Conference (2015)
Category: Imaging (radiology, nuclear medicine, endoscopy)
Presenting Author: Dr. Vikas Prasad
#50 Clinical-morphology correlation in diagnostics and evaluating surgery results of pancreatic insulinoma and nesidiobastosis
Introduction: Organic hyperinsulinism syndrome (OHS) is revealed in 85% cases of pancreas insulinoma. Nesidioblastosis (NB) induces OHS in 15% of the cases. Surgical cure provides all symptoms of insulinoma disappearing, while cytoreductive operation results in considerable improvement of life quality. There is no intraoperative opportunity to reveal insulinoma grade, even if an urgent biopsy is performed. Thus, it is essential to determine the cause of OHS and to apply the surgical cure method during the preoperational period, thereby improving the long-term prognosis.
Conference: 7th Annual ENETS Conference (2010)
Category: Basic
Presenting Author: Dr. Evelina Askenderova