Long-Term Haematological and Renal Toxicity of 90Yttrium-DOTA-Octreotate in the Treatment of Advanced Neuroendocrine Tumors(NETs)

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Introduction: Peptide receptor radiation therapy (PRRT) is an established treatment for advanced NETs. Renal/haematological toxicity are recognised adverse effects.

Aim(s): To assess the long-term toxicity of PRRT with Yttrium90-tyr3-DOTA-octreotate in progressive NETs.

Materials and methods: Two-hundred and thirty-five patients receiving 2.9-3.3 GBq/treatment cycle (with prophylactic aminoacid infusion) were included. Weekly serology was performed for eight weeks post cycle. Median 24 month follow-up results were analysed. Bone marrow (BMT) and renal (RT) toxicity patients were grouped according to severity: A (WHO grade 1-2) and B (grade 3-4).

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: MELVILLE A

Authors: Melville A, Cheung V, Garcia-Hernandez J, Pericleous M, Navalkissoor S,

Keywords: NET, PRRT, renal toxicity, bone marrow toxicity, Yttrium90,

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