Loss of Succinate Dehydrogenase (SDHB) in Midgut Carcinoids as Prognostic Factor: A New Marker of Personalized Cancer Medicine in Neuroendocrine Tumors? Abstract #645

Introduction: Gene mutations of the succinate dehydrogenase (SDH) complex are involved in the pathogenesis of cancer cells and play a pivotal role in angiogenesis and cell proliferation. The immunoistochemical (IHC) loss of SDHB is a marker of malignancy in pheocromocytomas and paragangliomas.
Aim(s): To evaluate SDHB expression in those neoplasia and its potential role as a prognostic marker.
Materials and methods: Thirty-one stage IV for synchronous liver metastases midgut G1 carcinoids were treated in our Institution. Twenty-five of 31 patients underwent surgical primary resection. IHC for SDHB and MIB1 were carried out in 20 primary tumors (T) and 19 liver metastases (M). SDHB was assessed according to the staining intensity scored 1 (low) or 2 (high) on the basis of the internal control represented by normal cells.
Conference: 10th Annual ENETS Conference (2013)
Category: Basic Science - mTOR and other pathways, signalling, receptors
Presenting Author: Md, PhD Massimo Milione
Keywords: midgut, SDHB

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