LRIG1 Was Down-Regulated in Medullary Thyroid Cancer but No Significant Effect of LRIG1 Was Found in RET2B Transgenic Mice and Human Differentiated Thyroid Cancer
#1587
Introduction: There are four main types of thyroid cancer, papillary (PTC), follicular (FTC), medullary (MTC), and anaplastic. In both PTC and MTC, genomic rearrangements and point mutations in the proto-oncogene RET are common. RET encodes a receptor tyrosine kinase that is negatively regulated by leucine-rich repeats and immunoglobulin-like domains-1 (LRIG1). LRIG1 gene status and mRNA and protein expression correlate with patient survival in different types of cancer.
Aim(s): The possible effect of LRIG1 expression in thyroid cancer was investigated in a mouse model and two different clinical cohorts.
Materials and methods: A transgenic mouse strain which ectopically expresses the human RET2B oncogene was crossed with Lrig1 knock-out mice. In the RET2B-positive offspring, calcitonin levels were measured and the thyroid glands were investigated by histology.
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author: Lindquist D
Authors: Lindquist D, Henriksson R, Hedman H,
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