Management of Metastatic Nonfunctional Pancreatic Neuroendocrine Tumor

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Introduction: Nonfunctional NETs themselves present in generally two ways, either with symptoms caused by the tumor compression of other organs, or found by imaging test performed for other reasons.

Aim(s): To present treatment tactics in case of metastatic nonfunctional pNETS.

Materials and methods: A 30-year-old female noticed intensive pain in the upper abdomen after a delivery in November 2006. A pancreatic lesion occupying the whole gland, multiple liver metastases and enlarged retroperitoneal lymph nodes were revealed by CT. The tumor biopsy showed it to be a somatostatin-producing NET with Ki-67 1-2%. Biotherapy with somatostatin and interferon was administered. Six months later, interferon treatment was stopped because of its side effects. In August 2008, the patient got worse because of migrating joint pain. Examinations showed bone and lung metastases, and chemotherapy with streptozotocin and zoledronic acid were prescribed.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Egorov A, Vasiliev I, Gurevich L, Kondrashin S, Parnova V,

Keywords: pancreas, nonfanctional tumor, metastase,