Introduction: The mixed adenoneuroendocrine carcinomas (MANEC, WHO 2010) are neoplasms with heterogeneous morphology, whose mixed nature may be difficult to recognize.
Aim(s): To increase the awareness of MANECs in colorectal carcinomas with signet-ring cell morphology.
Materials and methods: A series of four colorectal carcinomas with signet ring cell component (SRCC) in organoid pattern were studied for neuroendocrine (NE) differentiation. The cases were immunolabeled with antibodies to synaptophysin, Ki-67, p53, glucagon, serotonin, pancreatic-polypeptide (PP), SSTR2, Muc1, Muc2, Muc5a, CDX2, CK20, CK7, CK5/6, E-cadherin and ß-catenin. Clinical data are presented.
Conference: 9th Annual ENETS Conference (2012)
Presenting Author: MD Gratiana Hermann
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