MEN1-related Glucagonomatosis Incidentally Revealed During Management of Recurrent Intestinal Obstruction Following Surgery for Crohn’s Disease Abstract #1511

Introduction: Glucagonomas may present with varied intestinal symptoms,weight loss,diabetes and a typical rash. MEN1 related glucagonomas are extremely rare.
Aim(s): We present a case of MEN1-associated glucagonomas.
Materials and methods: Our case is a 64 year old lady with Crohn’s disease treated with multiple bowel resections 30 years ago, pelvic surgery and percutaneous radiation for a dysgerminoma, radiation for hyperthyroidism and surgery for a meningioma. She developed recurrent episodic intestinal obstruction following her last abdominal surgery, as well as a skin rash. Abdominal CT incidentally identified a 1.4cm lesion in the pancreatic neck investigated with EUS and FNA. Findings were suggestive for a NET.68-Ga DOTATATE PET/CT showed multiple tracer uptake foci in the pancreatic body and tail. Blood results included: gastrin 133pmol/L(≤60), glucagon 523pmol/L(≤50), chromogranin B 156pmol/L(<150), prolactin 3900ng/mL(<25). Serum calcium and PTH were normal. She underwent sub-total pancreatectomy with regional lymphadenectomy, splenectomy, cholecystectomy and adhesiolysis.
Conference: 13th Annual ENETS conference (2016)
Category: Clinical cases/reports
Presenting Author: MD, PhD Student Anna Malczewska
Keywords: MEN1, glucagonoma

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