Metastatic Gastrinoma Co-secreting PTHrP and ACTH Abstract #277

Introduction: Metastatic gastrinoma is occasionally associated with tumor secretion of functioning peptides, resulting in additional syndromes.
Aim(s): We present a case of pancreatic gastrinoma with hepatic metastases, secreting PTHrP and ACTH-producing Cushing’s Syndrome.
Materials and methods: A 46-year-old female presented with diarrhoea. US abdomen revealed an incidental hepatic mass. CT confirmed liver metastases with a primary pancreatic lesion. Pancreatic biopsy confirmed gastrinoma. Fasting gastrin levels >400pmol/L (0-60). Hypercalcaemia, hypokalaemia, proximal myopathy, abdominal distension, and altered mental state were noted.
Conference: 8th Annual ENETS Conference (2011)
Category: Clinical
Presenting Author: Dr Richard W Carroll

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