Methylguanine DNA Methyl Transferase (MGMT) Expression Predicts Response to Temozolamide in Patients with Digestive Neuroendocrine Tumors (NETs) Abstract #475

Introduction: Temozolomide (TEM) is an oral drug with encouraging results in pancreatic NETs (PNETs). MGMT tumor deficiency seems to be correlated with higher treatment efficacy.
Aim(s): To assess MGMT expression and its correlation with the efficacy of TEM in pts with NETs.
Materials and methods: Inclusion of pts with well-differentiated, progressive NETs treated with TEM. Treatment efficacy was defined according to RECIST. Pts with progression or stable disease were considered non-responders. Nuclear expression of MGMT was studied by immunohistochemistry and graded according to the intensity of staining (0 to 3) and the proportion of positive cells, leading to a score comprised between 0 and 300. A score>80 was defined as high.
Conference: 9th Annual ENETS Conference (2012)
Category: Clinical
Presenting Author: Dr Olivia Hentic

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