Introduction: The role of anti-angiogenic agents in GEP-NETS remains to be established. CD105 (Endoglin) identifies the TGF-ß1 receptor which is expressed on endothelial cells involved in tumor angiogenesis.
Aim(s): Preliminary study to determine the association between microvessel density (MVD), determined by CD105 expression, GEP-NET stage and prognosis.
Materials and methods: Thirty-nine patients with GEP-NETs were included in the study. A tissue microarray of tumor representative areas was made. After the immunohistochemical assay for CD105, CD31 and Ki-67, areas of the tumor with the largest number of micro-vessels (“hot spots”) were chosen and the number of microvessels per large magnification field was determined.
Conference: 8th Annual ENETS Conference (2011)
Presenting Author: Dr. Carlos A. S. Soares
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