Midkine is a New Novel Serum Biomarker in Small Intestinal Neuroendocrine Tumors (SI-NETs).
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Introduction: SI-NETs are often diagnosed late, which limits curative treatment options.
Aim(s): Our aim was to identify new novel biomarkers in SI-NETs, in order to enable early diagnosis, prognostication and monitoring of treatment response.
Materials and methods: Ninety-two biomarkers were screened in blood serum from 67 patients with SI-NETs and 23 age-matched healthy controls using multiplex proximity ligation assay (PLA). Confirmation of findings by multiplex PLA was performed by immunohistochemistry (IHC) on tumors, followed by ELISA assays in blood serum.
Conference: 13th Annual ENETSConcerence (2016)
Presenting Author: Daskalakis K
Authors: Daskalakis K, Edfeldt K, Norlén O, Karakatsanis A, Bäcklin C,
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