Mixed Adenoneuroendocrine Carcinoma (MANECs): A Rare and Challenging Subgroup of Neuroendocrine Neoplasia

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Introduction: Mixed Adenoneuroendocrine Carcinomas (MANECs) are rare entities in which at least 30% of neoplastic cells are neuroendocrine in nature (WHO 2010 classification). They result either from two independent lesions that merge together or are unique lesions with different cell populations intermingled.

Aim(s): To elucidate the clinical and histopathological characteristics of MANECs and to compare them to classic Neuroendocrine Neoplasias (NEN).

Materials and methods: Patients with NEN treated at two tertiary institutions were included in this analysis. A prospectively maintained database for NEN was searched for MANEC. The MANEC diagnosis was confirmed by conventional histopathology on surgical specimen. Ki-67 analysis was done on paraffin-embedded sections using immunohistochemistry. Grading was according to ENETS recommendations.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Mosli Lynch C, Flora R, Hanna G, Nicholson A, Speller A,

Keywords: mixed adenoneuroendocrine carcinoma, MANEC, neuroendocrine tumors,