Mixed Adenoneuroendocrine Carcinoma (MANECs): A Rare and Challenging Subgroup of Neuroendocrine Neoplasia Abstract #867

Introduction: Mixed Adenoneuroendocrine Carcinomas (MANECs) are rare entities in which at least 30% of neoplastic cells are neuroendocrine in nature (WHO 2010 classification). They result either from two independent lesions that merge together or are unique lesions with different cell populations intermingled.
Aim(s): To elucidate the clinical and histopathological characteristics of MANECs and to compare them to classic Neuroendocrine Neoplasias (NEN).
Materials and methods: Patients with NEN treated at two tertiary institutions were included in this analysis. A prospectively maintained database for NEN was searched for MANEC. The MANEC diagnosis was confirmed by conventional histopathology on surgical specimen. Ki-67 analysis was done on paraffin-embedded sections using immunohistochemistry. Grading was according to ENETS recommendations.
Conference: 11th Annual ENETS Conference (2014)
Category: Pathology, grading, staging
Presenting Author: Dr Conor Mosli Lynch

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