Molecular Imaging of Somatostatin Receptors with 68Ga-DOTATOC-PET in Patients with Meningioma

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Introduction: In vitro studies showed that meningioma cells may express somatostatin receptors (SSTRs), which bears the possibility of receptor-mediated radionuclide therapy in patients with meningioma.

Aim(s): To evaluate the application of 68Ga-DOTATOC-PET in patients with meningioma and the correlation between the expression of SSTRs in meningioma and gender, age of patients and tumor size.

Materials and methods: Twenty-five patients (14 f, 11 m; age 22-80 years) with meningioma were investigated with 68Ga-DOTATOC-PET (150 MBq, i.v.). Software-based coregistration of PET with MRI and/or CT was performed using Hybrid Viewer from Hermes Medical Solutions. Expression of SSTRs was classified in 4 grades [0, no uptake; 1, faint uptake; 2, moderate uptake; 3, high uptake (equal or higher than pituitary uptake)]. The tumor size (range 0.7-6.0 cm) was established on recent (< 48 hr) MRI and/or CT data.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Rodrigues M, Uprimny C, Nilica B, Waitz D, Iglseder S,

Keywords: 68Ga-DOTATOC, PET, meningioma, SSTRs,