Molecular Signature of Rectal Neuroendocrine Neoplasia Abstract #2965

Introduction: Rectal neuroendocrine tumors are rare neuroendocrine neoplasias (NEN). Little is known about prevalence and type of somatostatin receptor subtypes (sstr) expression and somatic mutations in relation to long-term clinical outcome.
Aim(s): To define molecular signatures that characterize distinct NEN within the intestinal tract (ileal, appendiceal and rectal NEN) and to explore whether molecular profiles mirror distinct tumor behaviour.
Materials and methods: Tumor specimens from 59 patients with NEN (12 appendiceal, 32 ileal (21 with distant metastases) and 15 rectal NEN (7 with distant metastases)) were analyzed. Expression of sstr2a and 5 was studied by immunohistochemistry and mutation screening was performed in 47 genes by next generation sequencing.
Conference: 17th Annual ENETS Conference 2020 (2020)
Category: Basic Science - Genetics, epigenetics, miRNAs, Omics
Presenting Author: Dr. Nicole Unger

To read results and conclusion, please login ...

Further abstracts you may be interested in

#245 Expression of Somatostatin Receptors and Dopamine 2 Receptor in Lung Carcinoids as a Possible Biotherapy Target
Introduction: Expression of somatostatin receptors (SSTRs) and dopamine 2 receptor (D2R) in neuroendocrine tumors is of clinical importance, as somatostatin analogues and dopamine agonists are used in biotherapy.
Conference: 8th Annual ENETS Conference (2011)
Category: Basic
Presenting Author: Dr Apostolos V. Tsolakis
#302 Monoclonal Antibodies Against the Human Somatostatin Receptor Subtypes 1-5: Characterization and Immunohistochemical Application in Gastrointestinal Neuroendocrine Tumors
Introduction: A lack of well-characterized somatostatin receptor (sstr)-specific antibodies has hampered development of routine sstr expression profiles that may be useful in the treatment of NET patients (pts).
Conference: 8th Annual ENETS Conference (2011)
Category: Clinical
Presenting Author: Chiara Lambertini
#1431 Expression of Somatostatin Receptors in Gastroenteropancreatic Neuroendocrine Neoplasm and Multicenter Retrospective Clinical Study of Octreotide LAR in the Treatment of Advanced GEP-NET
Introduction: Gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs) are known to overexpress somatostatin receptors(SSTRs),which forms the basis for octreotide long-acting repeatable(LAR) treatment in NEN.
Conference: 13th Annual ENETS conference 2016 (2016)
Category: Medical treatment - SMS analogues, interferon
Presenting Author: Chen Jie
Authors: Yuhong W, Wei W, Kaizhou J, Cheng F, ...
#1038 Co-Expression of Somatostatin and CXCR4 Receptors as Targets for Diagnostics and Treatment in Intestinal Neuroendocrine Neoplasms.
Introduction: Somatostatin receptors (SSTR) are widely distributed in well-differentiated neuroendocrine tumors (NET) and serve as primary targets for diagnostics and treatment. An overexpression of the chemokine receptor CXCR4, in contrast, is considered to be present mainly in highly proliferative and advanced carcinomas.
Conference: 12th Annual ENETS Conference 2015 (2015)
Category: Basic Science - mTOR and other pathways, signalling, receptors
Presenting Author: Dr. Daniel Kaemmerer
Keywords: sstr
#1641 Somatostatin Receptor Expression in Adrenocortical Carcinoma
Introduction: Adrenocortical carcinoma (ACC) is an uncommon neoplasm with an estimated annual incidence of 0.5-2 cases per million population. Surgery of the adrenal tumor is the major treatment. When complete tumor removal is not possible, or in case of recurrence, medical treatment with O,p’DDD(mitotane) is recommended. The treatment of ACC is currently based on the mitotane partial responses have been described in 19-34% of cases, and there are single reports of complete responses.The discovery of somatostatin (SST) and the identification of stable SST analogs with a longer half-life have raised new hopes for the treatment of endocrine tumors.
Conference: 14th Annual ENETS conference 2017 (2017)
Category: Medical treatment - SMS analogues, interferon
Presenting Author: Iya A Voronkova