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Monoclonal Antibodies Against the Human Somatostatin Receptor Subtypes 1-5: Characterization and Immunohistochemical Application in Gastrointestinal Neuroendocrine Tumors

#302

Introduction: A lack of well-characterized somatostatin receptor (sstr)-specific antibodies has hampered development of routine sstr expression profiles that may be useful in the treatment of NET patients (pts).

Aim(s): To characterize newly generated mouse monoclonal antibodies (mAbs) specific for the 5 sstr subtypes (1-5) in gastrointestinal NETs.

Materials and methods: We characterized the newly generated mouse mAbs specific for each of the five human sstr subtypes in a tissue microarray composed of 67 gastrointestinal NETs using immunohistochemical techniques. Expression data were correlated with clinicopathologic features such as WHO subtype, proliferative index, presence of angioinvasion, and metastases.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Lambertini C, Schmid H, Kaufmann M, Nuciforo P,

Keywords: Somatostatin receptor, neuroendocrine tumors, somatostatin receptor-specific monoclonal antibodies,

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