MTOR Controls an Epigenetic Program Leading to Autophagy and Cell Growth Control Abstract #1559

Introduction: Makroautophagy represents an evolutionary highly conserved process involved in the clearance of proteins and organelles. The induction of this central cellular process is tightly connected with programs regulating cell growth control. While the cytoplasmic machinery that orchestrates autophagy is relatively well understood the key epigenetic events that initiate autophagy-related cell growth programs remain largely unknown.
Aim(s): In this study we aim to understood epigenetic mechanisms controlling autophagy-related cell growth programs in neuroendocrine cancer cells.
Materials and methods: Using neuroendocrine cancer cells we studied cell growth, cell cycle, cell cycle-related protein expression and chromatin modifications following pharmacological inhibition or RNA interference (RNAi)-mediated suppression of mTOR and G9a.
Conference: 13th Annual ENETS conference (2016)
Category: Basic Science - Genetics, epigenetics, miRNAs
Presenting Author: Dr. Alexander Koenig

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