mTOR Down-Stream Signaling Pattern May Predict pNET Response to Everolimus Abstract #1086

Introduction: NETs are rare neoplasms arising from neuroendocrine cells spread in the respiratory and gastro-entero-pancreatic epithelium. The mammalian target of rapamycin (mTOR) pathway plays a central role in the regulation of cell growth, metabolism, and apoptosis representing a novel molecular target. This pathway is constitutively activated in pancreatic NETs (pNETs) providing the basis for the development of specific mTOR inhibitors as new therapeutic tools.
Aim(s): To investigate the effect of Eve, a mTOR inhibitor, on cell viability and apoptosis activation in pNETs and identify possible markers of the efficacy of mTOR inhibitors that may help in identifying the patients who may benefit from treatment with mTOR inhibitors.
Materials and methods: 20 pNET primary cultures were treated with IGF1 and/or Eve. Cell viability and caspase activity were evaluated. Alpha Screen Assays for PI3K/AKT/mTOR pathway components were performed.
Conference: 12th Annual ENETS Conference (2015)
Category: Basic Science - mTOR and other pathways, signalling, receptors
Presenting Author: PhD student Simona Falletta
Keywords: pNET, Everolimus, mTOR

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