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Multiple tumors in patients with pancreatic neuroendocrine tumours: morphological and immunohistochemical characteristics

#61

Introduction: Pancreatic islet cell tumors occur in 80% of patients with MEN 1. Tumors are often multicentric. They often produce multiple peptides and biogenic amines.

Aim(s): Improve immunophenotyping of multiple pancreatic neuroendocrne tumors.

Materials and methods: Immunophenotyping of the removed pancreatic neuroendocrine tumors (PNET) of 268 patients aged from 9 to 80 years old was carried out. MEN 1 syndrome was determined in 29 patients (10,8%). The neuroendocrine markers (chromogranin A, synaptophysin, CD56) and the hormones insulin, proinsulin, glucagon, somatostatin, gastrin, pancreatic polypeptide, serotonin, ACTH were used.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author:

Authors: Gurevich L, Egorov A, Askenderova E, Kubyshkin V, Kochatkov A,

Keywords: pancreatic islet cell tumor, pancreatic neuroendocrine tumor, MEN 1 syndrome, neuroendocrine marker, hormone,

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