Neuroendocrine and Ductal Breast Cancer Coexistence: An Unusual Case Report

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Introduction: Breast Primary Neuroendocrine carcinoma (BNEC) is a rare entity. Literature surveillance reveal few cases with no well-established therapeutic options. We herein report a case.

Aim(s): To present an unusual BNEC.

Materials and methods: We report a case of BNET in a 63-year-old female. The ultrasonography revealed irregular hypoechoic masses and mammography showed asymmetric breast tissue in the upper quadrant of the right breast. An excisional biopsy suggested carcinoma, and breast-conserving surgery with lymph node dissection was done. Histopathologic examination of the resected sample showed a solid to nested proliferation of neoplasmatic ductal cells of 1.5 cm and coexistence of a 2-cm lession that showed immunocytochemical positivity for chromogranin A, synaptophysin, CD56, and estrogen receptor. The overall evaluation did not show any metastatic sites. Octreoscan documented positive thoracic and abdominal nodes.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Vaslamatzis M, Alevizopoulos N, Laskarakis A, Theodora K, Mpallasis K,

Keywords: breast, NET, endocrine,