Neuroendocrine markers are expressed in human mammary glands

#46

Introduction: Regulatory peptides have previously been detected in epithelial cells of human mammary glands. As these peptides are produced by scattered neuroendocrine cells in the epithelium of other tissues the aim of this study was to investigate whether the mammary glands express molecular markers for neuroendocrine cells.

Aim(s): The aim of this study was to explore the expression of a set of neuroendocrine markers in normal breast tissue, and to reveal the cellular distribution of these molecules in mammary glands.

Materials and methods: Specimens from 28 human mammary glands were retrieved. The distribution of immunoreactive cells was determined using immunohistochemistry with antibodies versus a set of endocrine markers including peptide hormones, chromogranins/secretogranins, vesicular monoamine transporters, synaptophysin, serotonin and synaptic vesicle protein 2.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author:

Authors: Grönberg M, Amini R, Stridsberg M, Janson E, Saras J,

Keywords: Breast; Chromogranin; Ghrelin; Obestatin; Secretogranin; Vesicular monoamine transporter,