Neuroendocrine Neoplasms in Childhood and Adolescents

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Introduction: NEN are very rare tumors in children and adolescents with predominance in adolescent girls. The annual incidence is about 1.14:1 million. The most frequent localization is appendix. Bronchial NEN, even extremly rare, is the most frequent primary epithelial lung tumor in children.

Aim(s): Authors present retrospective monoinstitutional study of NEN in children and adolescents younger than 20 years of age treated in a pediatric cancer center within a period of 14 years.

Materials and methods: Retrospective analysis of 47 patients with NEN from four to 19 years of age. Median age 15 years for WDET, 14 years for NEC. Localization - appendix 42, jejunum 1, bronchi 1, liver 1, colon 1, neck 1. Histopathology - 43 WDET G1, 2 WDET G 2 and 2 NEC. All NEN are characteriued and treated according to ENETS Guidelines. All patients with WDET (appendix and jejunum) underwent R0 resection of the tumor, one girl with liver mets achieved CR after LTX. One girl with NEC (colon) underwent only biopsy, girl with MCC - R0 resection, RT and CHT.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Bajciova V

Authors: Bajciova V, Tuma J, Kren L, Prasek J,

Keywords: NEN in childhood and adolescents, incidence, localization, treatment, outcome,