Niacin (vitamin B3) Suppletion in Patients with Serotonin Producing Neuroendocrine Tumors

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Introduction: Tryptophan is the precursor of serotonin and niacin (vitamin B3), critical for normal cellular metabolism. Tryptophan and niacin can be deficient in patients with serotonin producing neuroendocrine tumors (NETs). Niacin deficiency can lead to symptoms including pellagra.

Aim(s): To assess niacin status before and after suppletion in these patients.

Materials and methods: We identified serotonin producing NET patients who had received oral niacin suppletion for tryptophan deficiency and/or pellagra associated symptoms. Pre-suppletion plasma tryptophan levels and niacin status based on the urinary niacin metabolite N1-methylnicotinamide (N1-MN) before (n=42) and after start suppletion (in 34 paired samples) were assessed.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Walenkamp A

Authors: Bouma G, Van Faassen M, Kats-Ugurlu G, De Vries E, Kema I,

Keywords: NET, Serotonin, Niacin, N1-methylnicotinamide.,