Introduction: Neuroendocrine tumors were considered rare tumors several years ago. Several reports published recently have observed increased incidence of NETs suggesting that NETs are more prevalent than previously reported. Non-functioning pancreatic endocrine tumors (NFPETs), better defined as non-hyperfunctioning, are characterized by the absence of clinical or biochemical evidence of hormone hypersecretion. From the clinical standpoint, NFPETs can be either occasionally encountered or manifest clinically similar pancreatic tumors. Since both NFPET treatment and prognosis significantly differ from that of ductal adenocarcinoma and other pancreatic malignant tumors, an accurate differential diagnosis is needed.
Aim(s): In this study we review our experience in treating non-functioning pancreatic endocrine tumors. The main aim was to evaluate diagnostic, as well as deferential diagnostic, criteria and surgical treatment options.
Materials and methods: Sixty-seven patients with NFPETs were enrolled in the first group of this study. All patients were operated on in the department of abdominal surgery of A.V. Vishnevsky Institute of Surgery from 1998 to 2008. All tumors were verified morphologically and immunohistochemicaly. The patients’ survival rate was calculated by Kaplan-Mayer method. We also analyzed data of 98 patients with pancreatic adenocarcinomas (the second group) in order to find differential diagnostic criteria of solid pancreatic tumors.
Conference: 7th Annual ENETS Conference (2010)
Presenting Author: Dr Alexander Vladimir Kochatkov
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