Novel Insights in Octreotide Effects on Human Neuroendocrine Cell Line CNDT2.5 Abstract #198

Introduction: Octreotide, the first synthetic somatostatin analog available for clinical use, efficiently binds somatostatin receptors (SSRs) 2 and 5 and may transduce its effects by using SSRs.
Aim(s): To elucidate molecular mechanisms of action of Octreotide in human neuroendocrine cell line CNDT2.5 by gene profiling.
Materials and methods: Gene profiling for CNDT2.5 cells was performed using Affymetrix microarrays. Q-RT-PCR and Western blots validated microarray results. Q-RT-PCR and immunohistochemistry were used to evaluate gene and protein expressions in neuroendocrine midgut primary tumor and metastasis tissues.
Conference: 8th Annual ENETS Conference (2011)
Category: Basic
Presenting Author: Su-Chen Li

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