Nuclear Imaging in Intermediate Grade Neuroendocrine Tumors

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Introduction: Early diagnosis and grading is essential to the treatment decision-making in neuroendocrine tumors. Conventionally, proliferation rate (Ki-67) level is used for the grading of NET. Ga-68 SMS-R PET/CT is the imaging method of choice for the detection of unknown primary neuroendocrine tumors. It is very sensitive in well-differentiated tumors (Ki-67 < 2%). Poorly and undifferentiated tumors having Ki-67 greater than 20% are primarily responsible for false negativity of Ga-68 SMS-R PET/CT. In those patients, FDG-PET is performed to localize the site of the primary tumor.

Aim(s): The data are scarce regarding the imaging modality of choice for intermediate grade (Ki-67 between 2 and 20%) NET. Our aim is to highlight the importance of FDG PET in grade 2 NET.

Materials and methods: Four patients with grade 2 NET (Ki-67 levels between 3% and 20%) of different primary locations (liver, pancreas and two mediastinal) underwent both Ga-PET and FDG-PET at the time of diagnosis.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Abou Yehia Z, Haydar A, Haydar M, Mukherji D, Temraz S,

Keywords: neuroendocrine tumors, nuclear imaging, histopathology ,