Optimizing Reconstruction Algorithm to Improve Quality of Post-PRRT Yittrium-90 PET Scan

#2013

Introduction: 90Y is commonly used in PRRT for NET. It has no gamma photon in its emission that significantly limits post-therapy imaging and dosimetry. Other than Bremsstrahlung imaging which bears hereditary drawbacks of poor resolution, PET scan has been used for post-PRRT imaging. However, in daily clinical practice, due to extremely low abundance of positron emission per decay and patient’s intolerability of prolonged scan time, it is very difficult to obtain a scan with decent quality.

Aim(s): Hence, we report our efforts to modify the reconstruction algorithm and consequently, to improve quality of post-PRRT 90Y PET imaging.

Materials and methods: GE 690 Discovery PET/CT scanner. 90Y-Dotatate is synthesized in radio-pharmacy in our department. The dose given to patients ranges from 80-160 mCi. Post-PRRT, 6 Patients were scanned of the focused area for 30 minutes. Acquired data were reconstructed by using 3 routine algorithms in our center and a purposely modified algorithm (namely LKYG) respectively. All images were blindly presented to 10 experienced nuclear medicine physicians for quality evaluation using a semi-quantitative scoring system. Scores of each algorithm were averaged and analysed using ANOVA and t-test.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Yan S

Authors: Yan S, Lim G,

Keywords: PRRT, PET scan, Yttrium 90, neuroendocrine tumor,