Pancreatic Neuroendocrine Neoplasms and Liver Metastases: When Size Matters

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Introduction: Small non-functioning pNENs are low grade indolent tumors, however distant metastases have also been documented in this subset of patients

Aim(s): We report our single-centre experience, comparing small pNENs (ø ≤2 cm) with larger ones, to describe their natural history in terms of OS and PFS and to detect specific prognostic factors related with the risk of liver metastases (LM)

Materials and methods: Kaplan-Meyer curves were calculated for OS and PFS. Logistic binary regression and Cross-Tabs OR were performed for age, primary tumor diameter, CgA levels and mib-1 to estimate factors independently related with LM and the probability of developing distant metastases

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Monteleone M, Rossi R, Altomare M, Prinzi N, Cattaneo L,

Keywords: Pancreatic neuroendocrine neoplasia, Liver metastases,