Pancreatic Neuroendocrine Tumor in Polish Population with MEN 1 Syndrome

#2076

Introduction: The multiple endocrine neoplasia type 1 (MEN 1) is a genetically conditioned syndrome which is characterised by usually mild parathyroid and pituary gland adenomas, pancreatic neuroendocrine tumor (pNET). The last appear in 30-70% of MEN 1 patients being main life-threatening manifstation among MEN 1 patients. The prognosis might improve by presymptomatic tumor detection.

Aim(s): The aim of this study was to evaluate the Polish population of patients with MEN1 and diagnosed pNET. The evaluation consisted of clinical and genetic characteristics and provided therapy.

Materials and methods: Data was collected on the basis of retrospective analysis of medical history of patients with clinical suspicion of MEN 1 from 4 Polish endocrinological centres. In 695 patients a MEN 1 sequencing was conducted. Polymorphism in a gene was diagnosed in 85 patients.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Soczomski P, Jurecka-Lubieniecka B, Rogozik N, Grajewska-Ferens M, Michalik B,

Keywords: Multiple endocrine neoplasia, Menin, Pancreatic Neuroendocrine Tumor, Polish population,