Pancreatic Neuroendocrine Tumor Presenting in Pregnancy with Severe Hypercalcemia Abstract #810

Introduction: Malignant hypercalcemia secondary to pancreatic neuroendocrine tumor (pNET) is a rare occurrence with no standard management. We report a challenging case of pNET presenting during pregnancy and complicated by severe hypercalcemia.
Aim(s): We discuss the mechanisms of hypercalcemia and the therapeutic interventions used.
Materials and methods: A 23-year-old woman presented at 26 weeks of gestation with persistent vomiting. MRI showed large pancreatic mass and innumerable liver lesions. Biopsy revealed well-differentiated NET having a Ki-67 of 15%. She commenced sandostatin LAR, however, presented four weeks later with severe hypercalcemia of 20 mg/dl (8.5-10.5 mg/dl). PTH was suppressed but PTHrP elevated.
Conference: 11th Annual ENETS Conference (2014)
Category: Clinical cases/reports
Presenting Author: MD Rita E Assi

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