Past Guidelines and Standards of Care

ENETS Guidelines, TNM Grading, Standards of Care and Metastases

The 2012 ENETS Consensus Guidelines for the Diagnosis and Treatment of Neuroendocrine Tumors are as follows:

• Introduction
• Gastroduodenal Neoplasms
• Colorectal Neuroendocrine Neoplasms
• Functional Pancreatic Endocrine Tumor Syndromes
• Well-differentiated Pancreatic Non-Functioning Tumors
• Neuroendocrine Neoplasms from the Jejuno-Ileum and the Appendix, including Goblet Cell Carcinomas
• Liver and Other Distant Metastases from Neuroendocrine Neoplasms of Foregut, Midgut, Hindgut and Unknown Primary

In 2010, members of the ENETS Advisory Board and other select experts were invited to contribute to four papers focusing on metastases:

• Introduction: Rare metastases
• Brain, cardiac and ovarian metastases
• Peritoneal carcinomatosis
• Bone and lung metastases

In 2009, a select group of Society members, headed by Ursula Plöckinger at the Charité - Universitätsmedizin Berlin (Charité University Hospital), completed work on and published the ENETS Consensus Guidelines for the Standard of Care for Patients with Digestive Neuroendocrine Tumors:

• ENETS Standard of Care Guidelines introduction
• Diagnosis and Prognostic Stratification
• Radiological Examinations
• Stomatostatin Receptor Imaging
• Echocardiography
• Biochemical Markers
• Pre- and Perioperative Therapy
• Biotherapy
• Chemotherapy
• PRRT with Radiolabeled Stomatostatin Analogs
• Follow-up and Documentation

Please find below the 2005-2007 revised ENETS Consensus Guidelines for the Diagnosis and Treatment of Neuroendocrine Tumors. The Guidelines were published in Neuroendocrinology in 2006 and in 2008.

• Foregut introduction
• Gastrinoma duodenal pancreatic
• Insulinoma
• Liver metastases foregut midgut hindgut and unknown primary
• Midgut and Hindgut introduction
• Poorly differentiated carcinomas foregut gastric duodenal pancreatic
• Poorly differentiated endocrine carcinomas of midgut and hindgut origin
• Rare functioning pancreatic endocrine tumors
• Well-differentiated appendix goblet cell tumors
• Well-differentiated colon and rectum tumors
• Well-differentiated duodenal tumors
• Well-differentiated gastric tumors
• Well-differentiated jejunal-ileal tumors
• Well-differentiated pancreatic nonfunctioning tumors

Below are the TNM classifications for foregut, midgut and hindgut tumors, published in Virchows Archiv in 2006 and in 2007. Once you open the link, please click on the PDF logo to access the full article:

• TNM staging of foregut neuroendocrine tumors: A consensus proposal including a grading system: springerlink.com/content/73275014p722011q
• TNM staging of midgut and hindgut neuroendocrine tumors: A consensus proposal including a grading system: springerlink.com/content/7rjg872752462r55